What are the challenges of conducting double-blind studies for rare diseases?

A double-blind, placebo-controlled, randomized study was performed to determine whether proglumide added to ongoing neuroleptic medication was efficacious ... A clinical trial design in which neither the participating individuals nor the study staff knows which participants are receiving the experimental drug and ... Jan 23, 2025 ... This prospective, double-blind, test accuracy study was designed to test whether an artificial intelligence (AI)–guided software device (AutoDVT) could support ... Jan 22, 2021 ... The aim of this randomized, double-blind phase II/III study was to assess the efficacy of axitinib in patients with advanced G1-2 extra-pancreatic NETs. Feb 1, 2022 ... A double blind trial is a trial where neither the researchers nor the patients know what they are getting. The computer gives each patient a ... A double-blind, randomized, prospective study was undertaken to determine if the dose of OKT3 used for induction immunosuppression following kidney and ... Abstract. In a double-blind trial in 21 patients with spasmodic torticollis botulinum-A toxin produced both subjective and objective improvement, including ... In a double-blind study, neither the patients nor the researchers/doctors know which study group the patients are in. In a triple-blind study, the patients ... In a blind or blinded experiment, information which may influence the participants of the experiment is withheld until after the experiment is complete. May 15, 2020 ... Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis.