What are the challenges in developing highly specific S-phase inhibitors?

(2010). A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS ... Mar 30, 2021 ... In addition, caspase-2-deficient cells have a higher frequency of stalled replication forks, decreased DNA fiber length, and impeded progression ... Jan 29, 2024 ... Metastasis in ovarian cancer typically occurs through three ... induces apoptosis and cell cycle arrest at the S phase in. SKOV-3 ... Dec 4, 2019 ... ... cells are sometimes preferentially lost, the fewer manipulations the better. Etoposide induces apoptosis which results in a S phase cell cycle ... Feb 2, 2025 ... DNA is replicated during S phase. Cell division happens during M phase, which includes mitosis (chromosoma formation and segregation between the ... Furthermore, the cell-cycle phase may directly regulate DNA end resection as resection occurs fastest in S phase and CtIP-dependent resection is upregulated by ... Oct 13, 2019 ... In G1-phase cells are growing and preparing for DNA replication. The DNA replication thereafter takes place during S-phase, where the cellular ... The somatic cell cycle consists of 3 phases: interphase, m phase, and cytokinesis. ... During S phase, each chromosome is replicated. This produces a ... The G0/G1 and G2/M curves are fit using the same process as the Watson model. The difference occurs in the fit of the S phase. The Dean-Jett model fit a second ... Two gap phases precede the S and M phases; in G1 the cell prepares for DNA synthesis, and in G2 the cell prepares for the mitotic division that takes place in ...