How can we ensure equitable access to S-phase targeting therapies?

H. Stuck in division or passing through: what happens when cells ... C. CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage. Jan 29, 2024 ... Metastasis in ovarian cancer typically occurs through three ... induces apoptosis and cell cycle arrest at the S phase in. SKOV-3 ... Apr 1, 2019 ... We show here that small molecule 2-[(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl]phenol (THTMP), a potential anticancer agent, increases the human ... If a mutation occurs in a protein that regulates the cell cycle, e.g. p53 ... In which phase of the cell cycle is DNA replicated? G1 phase. S phase. G2 ... During G1 phase, growth-dependent cyclin-dependent kinase (CDK) activity promotes DNA replication and initiates G1-to-S phase transition. Actively dividing eukaryote cells pass through a series of stages known collectively as the cell cycle: two gap phases (G1 and G2); an S (for synthesis) ... Cells prepare for DNA replication in S phase by loading MCMs at replication origins in the preceding G1 phase, a process called “origin licensing.” The amount ... In the first phase (G1) the cell grows and becomes larger. When it has reached a certain size it enters the next phase (S), in which DNA-synthesis takes place. 1 expression and S-phase progression provides a “synchromesh” mechanism that “locks” the erythroid differentiation program to the cell cycle clock, ensuring ... Jan 28, 2010 ... Progress in plant cell cycle research is highly dependent on reliable methods for detection of cells replicating DNA. Frequency of S-phase ...