How does replication stress contribute to genomic instability in cancer?

Figure 1: A cell moves through a series of phases in an orderly manner. During interphase, G1 involves cell growth and protein synthesis, the S phase involves ... Furthermore, the cell-cycle phase may directly regulate DNA end resection as resection occurs fastest in S phase and CtIP-dependent resection is upregulated by ... Dec 16, 2021 ... In the G2 phase the cell is in the last phase before it officially divides. The cell in the G2 also increases in size much more and goes through ... Dec 18, 2006 ... This suppression during S phase is apparently regulated by cell cycle position alone and occurs automatically during each cell cycle. If the ... In order to ensure that replication occurs only once per cell cycle, geminin inhibits and destabilizes CDT1 during the S, G2 and M phases. At the metaphase/ ... Cells prepare for DNA replication in S phase by loading MCMs at replication origins in the preceding G1 phase, a process called “origin licensing.” The amount ... Mar 30, 2021 ... In addition, caspase-2-deficient cells have a higher frequency of stalled replication forks, decreased DNA fiber length, and impeded progression ... Mar 28, 2018 ... Silkworm Pupa Protein Hydrolysate Induces Mitochondria-Dependent Apoptosis and S Phase Cell Cycle Arrest in Human Gastric Cancer SGC-7901 Cells. Jan 11, 2021 ... Although CDK4/6 inhibitors are an established treatment for hormone receptor–positive, HER2-negative metastatic breast cancers, their benefit in ... It is generally believed that this type of repair occurs preferentially in the late S, G2 and M phases of the cell cycle, when the sister chromatid is ...