How can we develop more precise and targeted therapies that exploit vulnerabilities related to S phase defects in these diseases?

Mar 30, 2021 ... In addition, caspase-2-deficient cells have a higher frequency of stalled replication forks, decreased DNA fiber length, and impeded progression ... In the first phase (G1) the cell grows and becomes larger. When it has reached a certain size it enters the next phase (S), in which DNA-synthesis takes place. Mar 11, 2019 ... The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases ... Oct 13, 2019 ... In G1-phase cells are growing and preparing for DNA replication. The DNA replication thereafter takes place during S-phase, where the cellular ... DNA is replicated during the S phase of. Mitosis versus meiosis. Before division, the cell is diploid, with two unique sets. Image source: By Gabi Slizewska. May 10, 2023 ... The S phase of a cell cycle occurs during interphase, before mitosis or meiosis, and is responsible for the synthesis or replication of DNA. S phase (Synthesis phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. Since accurate duplication of ... ... during the S-Phase of the cell cycle. Measurement of DNA synthesis is therefore essential for research in many scientific fields, such as assessing cell ... Figure 1: A cell moves through a series of phases in an orderly manner. During interphase, G1 involves cell growth and protein synthesis, the S phase involves ... During G1 phase, growth-dependent cyclin-dependent kinase (CDK) activity promotes DNA replication and initiates G1-to-S phase transition.