How do histone modifications affect the progression of the replication fork?

E.g. antimetabolites such as methotrexate work in the S phase (synthesis phase) of the cell cycle. Intravenous antineoplastic drugs are administered in the ... In fact, the accumulation of cells in S phase was found to be a gradual process that occurs over several cell cycles, as shown in Fig. 2 B for ... 1 expression and S-phase progression provides a “synchromesh” mechanism that “locks” the erythroid differentiation program to the cell cycle clock, ensuring ... The G0/G1 and G2/M curves are fit using the same process as the Watson model. The difference occurs in the fit of the S phase. The Dean-Jett model fit a second ... The S phase, occurring between the G1 and G2 phases of the cell cycle, is when DNA replication and much of the DNA repair activity occurs in cells. If a mutation occurs in a protein that regulates the cell cycle, e.g. p53 ... In which phase of the cell cycle is DNA replicated? G1 phase. S phase. G2 ... What occurs during the S phase of the cell cycle? 1) the genetic material is copied, 2) chromosomes replicate and become double stranded chromatids. In order to ensure that replication occurs only once per cell cycle, geminin inhibits and destabilizes CDT1 during the S, G2 and M phases. At the metaphase/ ... In S phase, the cell synthesizes a complete copy of the DNA in its nucleus. It also duplicates a microtubule-organizing structure called the centrosome. The ... S phase (Synthesis phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. Since accurate duplication of ...