How can inhibitors of DNA repair pathways be used in combination with S-phase targeting drugs?

... phase become less radiosensitive than they are in other phases of the cell cycle. This paper is only available as a PDF. Keywords. Granulocyte/macrophage ... The eukaryotic cell spends most of its "life" in interphase of the cell cycle, which can be subdivided into the three phases, G1, S and G2. Cell division is ... 32 What happens during the S phase? DNA synthesis or replication. 33 Each chromosome originally is made of how many DNA molecules and how does this molecule ... Dec 4, 2019 ... ... cells are sometimes preferentially lost, the fewer manipulations the better. Etoposide induces apoptosis which results in a S phase cell cycle ... The S phase, occurring between the G1 and G2 phases of the cell cycle, is when DNA replication and much of the DNA repair activity occurs in cells. Then, at a critical point during interphase (called the S phase), the cell duplicates its chromosomes and ensures its systems are ready for cell division. If ... May 13, 2018 ... Sinomenine, a bioactive alkaloid isolated from the traditional Chinese herb Sinomenium acutum, possesses antiinflammatory, antinociceptive, ... The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK). Jan 11, 2013 ... The correlations between Mirk/Dyrk1B expression and active ERK1/2 detected by western blot in both ovarian cancer and non-small cell lung cancer ... S phase (Synthesis; when the copying of DNA happens). ... These attack cancer cells during specific phases of the cell cycle, but never during the resting phase.