Can interventions that target or modulate the S phase have therapeutic benefits for aging and age-related conditions?

Aug 21, 2023 ... 3: TRAIP is essential for S-phase progression during unperturbed cell cycle. ... This progression can also happen without chromosome ... What occurs during the S phase of the cell cycle? 1) the genetic material is copied, 2) chromosomes replicate and become double stranded chromatids. May 1, 2008 ... This indicates nuclear DNA synthesis occurs during development. Mitosis and early S phase were both twofold longer in slugs as compared with ... Apr 1, 2019 ... We show here that small molecule 2-[(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl]phenol (THTMP), a potential anticancer agent, increases the human ... S phase. S stands for Synthesis phase. In this phase, the DNA in the cell is replicated, so that the two daughter cells can each get one ... (2010). A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS ... Sep 12, 2024 ... During S phase, DNA synthesis occurs in preparation for subsequent rounds of cell division. A small molecule called 2[[3-(2,3-dichlorophenoxy) ... During G1 phase, growth-dependent cyclin-dependent kinase (CDK) activity promotes DNA replication and initiates G1-to-S phase transition. Cells prepare for DNA replication in S phase by loading MCMs at replication origins in the preceding G1 phase, a process called “origin licensing.” The amount ... The eukaryotic cell spends most of its "life" in interphase of the cell cycle, which can be subdivided into the three phases, G1, S and G2. Cell division is ...