What is the role of ongoing basic research in furthering our understanding of the fundamental causes of Down syndrome and identifying new therapeutic targets?

Down syndrome, the most common genetic birth defect, is caused by the presence of an extra chromosome. Genes carry the “instructions” for every part of our ... Physical signs of Down syndrome · A flat nose bridge. · Slanted eyes that point upward. · A short neck. · Small ears, hands and feet. · Weak muscle tone at ... Jan 30, 2023 ... Cardiovascular disease is a leading cause of morbidity and mortality in individuals with Down syndrome. Congenital heart disease is the most ... Dermatological manifestations of Down syndrome, Trisomy 21 syndrome, Complete trisomy 21 syndrome ... What causes Down syndrome? A cell division error during ... Mar 18, 2021 ... This additional chromosome, or portion of a chromosome, causes the common features of DS: delayed language; impaired long and short-term memory; ... Down syndrome is a genetic condition caused by extra copies of chromosome 21. It results in certain characteristics, including some degree of cognitive ... Apr 20, 2023 ... The cause of Down syndrome is known to be an extra copy of chromosome 21, or trisomy 21. But because this chromosome contains more than 200 ... This extra genetic material causes the physical features and developmental delays in people with Down syndrome. The features are no different if the extra ... Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. Fetuses with Down syndrome have an extra copy of chromosome 21, resulting in 47 chromosomes total. This excess genetic material causes the physical and mental ...