What are the advantages and disadvantages of targeting host ribosomes versus viral components for antiviral therapy?

ribosome function; ribosome stalling; RNA-protein interaction; RQC; translation. Access to Document. 10.1016/j.jbc.2022.102774. Other files and links. Link to ... →What is the role of the nucleus in eukaryotic cells? ... The proteins produced by the ribosomes are then used to perform a wide range of functions within the ... Jan 15, 2020 ... BUD23 links ribosome function with mitochondrial protein expression and efficient oxidative phosphorylation by promoting selective mRNA ... Finally, they visualised ribosomes in neuronal processes, which revealed the predominant role of monosomes in neuronal translation and further confirmed the ... Oct 14, 2024 ... Ribosomes are responsible for translating the genetic code carried by mRNA into a functional protein, a process known as translation. Apr 21, 2024 ... Here we report the discovery of a new general translation factor that targets stalled ribosomes and promotes protein synthesis in an evolutionarily conserved ... The ribosome is universally responsible for synthesizing proteins by translating the genetic code transcribed in mRNA into an amino acid sequence. Jul 1, 2001 ... The mechanisms that underlie ribosomal synthesis, translocation and catalysis are now being unravelled, with practical implications for the design of ... Yonath, “for studies of the structure and function of the ribosome“. At the ... As ribosomes are crucial for life, they are also a major target for new ... Role and structure of ribosomes. Topic: Translation. mRNA is translated into a polypeptide chain (and therefore a protein) at ribosomes ...