How do ribosomes sense and respond to ER stress?

A ribosome functions as a micro-machine for making proteins. Ribosomes are composed of special proteins and nucleic acids. Feb 10, 2023 ... Most eukaryotic ribosome biogenesis factors were first identified by genetic screens and proteomic approaches of pre‐ribosomal particles in Saccharomyces ... Ribosomes serve as translation machinery in the cell and are a complex assembly of rRNAs and a large number of ribosomal proteins and ribosome-associated ... The ribosome is universally responsible for synthesizing proteins by translating the genetic code transcribed in mRNA into an amino acid sequence. Ribosomes play a crucial role in the process of translation by reading the sequence of codons on mRNA and catalysing the formation of peptide bonds between ... Cotranslationally acting Hsp70 meets the challenge of folding the eukaryotic proteome by stabilizing its longer, more slowly translated, and aggregation prone ... Apr 21, 2024 ... Here we report the discovery of a new general translation factor that targets stalled ribosomes and promotes protein synthesis in an evolutionarily conserved ... Jan 17, 2013 ... Summary. In eukaryotic cells a molecular chaperone network associates with translating ribosomes, assisting the maturation of emerging nascent ... Feb 24, 2021 ... Summary. For this talk, Dr. Green will describe her laboratory's recent efforts to define how ribosome elongation distress is connected to ... Jan 31, 2025 ... Ribosomes appear to 'help' each other in navigating difficult-to-translate RNA sections, a phenomenon they call 'ribosome cooperativity'. “This ...