What are the societal costs associated with hearing loss and balance disorders related to stereocilia dysfunction?

Feb 22, 2024 ... Today's #LabVocab is stereocilia – a part of the ear that plays a critical role in how humans experience sound and balance. Mar 11, 2019 ... The tip links are connected to stretch-activated cation channels on the tips of the stereocilia. When a sound wave vibrates the basilar membrane ... Mar 27, 2024 ... Using scanning electron microscopy and super-resolution microscopy, we investigate stereocilia formation from hair cell specification stages in the mouse organ ... Jun 3, 2019 ... Noise-induced hearing loss happens when tiny hair-like structures (stereocilia) that sit on top of hair cells in the inner ear are damaged by noises that are ... You are studying the mechanism by which stereocilia in inner ear hair cells bend and transduce a ... staining reveals that it is located at the base of ... May 24, 2023 ... Stereocilia are vital for the transmission of sound as they house the mechanoelectrical transduction channels triggered by the bending of the ... We previously reported that CIB2 binds to WHRN and is essential for stereocilia staircase architecture of cochlear hair cells. Here, we refine the ... Apr 23, 2009 ... ... stereocilia," which are the 50 to 300 hair-like nanotubes projecting ... stereocilia bundles atop those cells—also amplify sound by ... Jul 22, 2024 ... We conclude that stereocilia fusion is linked with the failure to maintain cellular proteostasis and with disturbances in stereociliary calcium balance. Male Smpx null mice showed a progressive hearing loss starting from high frequency at the 3rd month. Hearing loss in female mice was milder and occurred later.