How does Waardenburg syndrome affect hearing and pigmentation?

Jul 1, 1980 ... From our results, we conclude that the stereocilia of the ear, unlike the brush border of intestinal epithelial cells, are not designed to ... This article obtains the stereocilia movement generated by basilar membrane (BM) vibration based on the positional relationship between the various structures ... Deflection of the bundle of stereocilia is mechanically responsible for stretching ion pores in the stereocilia, allowing a cation current to pass into the cell ... Many experimental observations over the past decade have indicated that the role of stereocilia structure and function in cochlear hair-cell transduction is ... Oct 1, 2023 ... The stereocilia of these cells help to adsorb any remaining fluid and pass nutrients to the stored sperm to support their viability. Other ... When your head moves, the endolymph moves the cupula and stimulates the stereocilia. Vertigo is a feeling of dizziness or sudden sensation of spinning when ... We previously reported that CIB2 binds to WHRN and is essential for stereocilia staircase architecture of cochlear hair cells. Here, we refine the ... Jul 18, 2022 ... Espins are actin-bundling proteins that have a well-characterized role in stereocilia formation; loss of function mutations in Espin result in ... These results suggest that regulation of stereocilia length occurs through EPS8 and that CDH23 and PCDH15 regulate stereocilia lengthening beyond their role in ... May 21, 2018 ... These tiny fibers form bundles sitting atop sensory hair cells deep inside your inner ear, and give them their name. Stereocilia are as ...