What are the potential off-target effects of gene therapy for hearing loss?

For the latter option to work without downtime, each stereocilium (or sets of mechanically-connected stereocilia) must be able to execute the recovery by itself ... ... stereocilia? How did the authors explain inconsistencies with previous published results by Ohmori? c) What was the nature of the evidence that transduction ... stereocilia it connects. It also explains the very similar rotational operating range encountered in VHCs and. OHCs of the neonatal mouse, as their rootlet ... Aug 13, 2024 ... Within the inner ear lies the cochlea, which is your organ of hearing, and it houses tiny nerve endings called stereocilia. Sensorineural ... Mar 11, 2019 ... The tip links are connected to stretch-activated cation channels on the tips of the stereocilia. When a sound wave vibrates the basilar membrane ... Jan 21, 2021 ... Abstract. Inner ear hair cells detect sound-induced displacements and transduce these stimuli into electrical signals in a hair bundle that ... May 24, 2023 ... Stereocilia are miniscule hair-like protrusions on the surface of sensory cells (also called hair cells) found deep within the cochlear and ... Feb 9, 2022 ... These cells possess stereocilia connected to the tectorial membrane. ... During auditory stimulation, sound waves in the cochlea cause deflection ... They are distinct from cilia and microvilli, but are closely related to microvilli. They form single "finger-like" projections that may be branched, with normal ... Jun 11, 2013 ... Stereocilia are bundles of bristly projections that extend from the tops of sensory cells, called hair cells, in the inner ear. Each stereocilia ...