What are the possibilities that lie ahead in the quest to understand and restore the remarkable sensory abilities of the inner ear?

Jul 8, 2022 ... Inside the inner ear is the cochlea, which is lined with tiny hair cells called stereocilia. The stereocilia's job is to convert sound waves ... Jul 22, 2024 ... We conclude that stereocilia fusion is linked with the failure to maintain cellular proteostasis and with disturbances in stereociliary calcium balance. Apr 21, 2025 ... Cilia are made of microtubules, while stereocilia and microvilli are made of actin filaments. The shortest is microvilli, intermediate height ... These results provide the first direct evidence that type I hair cells have significantly more stereocilia than type II hair cells. Apr 13, 2017 ... Because the actin filaments in the stereocilia of hair borders still remain as compact bun- dles, albeit very disordered, there must be an addi-. Apr 6, 2016 ... ... stereocilia. While functionally very different, the protein complexes that organize microvilli and stereocilia have striking parallels. Both ... The stereocilia of each hair cell are arranged in a precise geometry. This arrangement is asymmetrical and polarized because the stereocilia are arranged in ... Oct 13, 2017 ... These two models could be tested by manipulating Ca2+ or actin-depolymerizing molecules in the stereocilium and examining effects on stereocilia ... Male Smpx null mice showed a progressive hearing loss starting from high frequency at the 3rd month. Hearing loss in female mice was milder and occurred later. Oct 4, 2006 ... The staircase-shaped stereocilia bundle of the inner ear sensory hair cells detect mechanical stimuli by the activation of mechanoelectrical ...