What are the physiological mechanisms by which stress might impact stereocilia?

Feb 9, 2022 ... These cells possess stereocilia connected to the tectorial membrane. ... During auditory stimulation, sound waves in the cochlea cause deflection ... Bending the stereocilia away from the kinocilium hyperpolarizes the cell and results in a decrease in afferent activity. The semicircular ducts work in pairs to ... Trouble detecting soft or high-pitched sounds is often the first sign that stereocilia — the delicate hair cells that convert sound waves into electrical ... Male Smpx null mice showed a progressive hearing loss starting from high frequency at the 3rd month. Hearing loss in female mice was milder and occurred later. Jun 3, 2019 ... Noise-induced hearing loss happens when tiny hair-like structures (stereocilia) that sit on top of hair cells in the inner ear are damaged by noises that are ... These results suggest that regulation of stereocilia length occurs through EPS8 and that CDH23 and PCDH15 regulate stereocilia lengthening beyond their role in ... May 21, 2018 ... These tiny fibers form bundles sitting atop sensory hair cells deep inside your inner ear, and give them their name. Stereocilia are as ... We previously reported that CIB2 binds to WHRN and is essential for stereocilia staircase architecture of cochlear hair cells. Here, we refine the ... The stereocilia are simpler, containing only an actin cytoskeleton. Each stereocilium tapers where it inserts into the apical membrane, forming a hinge ... Aug 23, 2016 ... Abstract. Stereocilia are actin-based protrusions on auditory and vestibular sensory cells that are required for hearing and balance. They ...