How can we deliver therapeutic genes specifically to hair cells?

Male Smpx null mice showed a progressive hearing loss starting from high frequency at the 3rd month. Hearing loss in female mice was milder and occurred later. Answer and Explanation: 1. The main function of the stereocilia exhibited by the epithelial cells of the mucosa of the epididymis is to absorb the fluid ... Trouble detecting soft or high-pitched sounds is often the first sign that stereocilia — the delicate hair cells that convert sound waves into electrical ... Nov 3, 2021 ... ... stereocilia. Sound vibrations cause the stereocilia to sway, which leads to the hair cell sending signals to nearby neurons that relay ... They have more stereocilia and long stereocilia relative to kinocilia heights. Tip link tensions show parallel behavior in peripheral columns of the bundle ... Oct 18, 2022 ... Stereocilia movements create an electrical signal that the auditory nerve carries to the brain. But accurately capturing and interpreting the ... Apr 18, 2024 ... Question: what is the function of the stereocilia exhibited by the epithelial cells of the mucosa of the epididymis ... Here's the best way to ... We previously reported that CIB2 binds to WHRN and is essential for stereocilia staircase architecture of cochlear hair cells. Here, we refine the ... Oct 4, 2006 ... The staircase-shaped stereocilia bundle of the inner ear sensory hair cells detect mechanical stimuli by the activation of mechanoelectrical ... Jul 22, 2024 ... We conclude that stereocilia fusion is linked with the failure to maintain cellular proteostasis and with disturbances in stereociliary calcium balance.