How do mutations in stereocilia-related genes lead to hearing loss or balance disorders?

These results suggest that regulation of stereocilia length occurs through EPS8 and that CDH23 and PCDH15 regulate stereocilia lengthening beyond their role in ... a hair bundle containing stereocilia, or sensory hairs, that project upward into the tectorial membrane, which lies above the stereocilia in the cochlear duct. Jan 21, 2021 ... Abstract. Inner ear hair cells detect sound-induced displacements and transduce these stimuli into electrical signals in a hair bundle that ... Oct 18, 2022 ... Stereocilia movements create an electrical signal that the auditory nerve carries to the brain. But accurately capturing and interpreting the ... They are distinct from cilia and microvilli, but are closely related to microvilli. They form single "finger-like" projections that may be branched, with normal ... stereocilia it connects. It also explains the very similar rotational operating range encountered in VHCs and. OHCs of the neonatal mouse, as their rootlet ... ... stereocilia. These stereocilia are grouped into hair bundles, and the stereocilia in each hair bundle work together to facilitate the conversion of physical ... The actin filament bundle, which is held together by specific crossbridges, gives rigidity and exact dimensions to each stereocilium. The cuticular plate ... Jan 25, 2016 ... ... stereocilia. While functionally very different, the protein complexes that organize microvilli and stereocilia have striking parallels. Both ... Deflection of the bundle of stereocilia is mechanically responsible for stretching ion pores in the stereocilia, allowing a cation current to pass into the cell ...