How do cochlear implants bypass the damaged hair cells and stimulate the auditory nerve?

Mar 21, 2011 ... The mechanotransducer channels of auditory hair cells are gated by tip-links, oblique filaments that interconnect the stereocilia of the ... ... stereocilia functional architecture and self-renewal. Rzadzinska AK 1 ,. Schneider ME ,. Davies C ,. Riordan GP ,. Kachar B. Author information. Affiliations. 1 ... Trouble detecting soft or high-pitched sounds is often the first sign that stereocilia — the delicate hair cells that convert sound waves into electrical ... The stereocilia of each hair cell are arranged in a precise geometry. This arrangement is asymmetrical and polarized because the stereocilia are arranged in ... Dec 4, 2021 ... The longer stereocilia that project from the outer hair cells actually attach to the tectorial membrane. All of the stereocilia are ... Feb 22, 2024 ... Loud noise is causing zinc, normally localized to stereocilia, to be blasted over many Zinc in the inner ear is concentrated in stereocilia ... Jun 3, 2019 ... Noise-induced hearing loss happens when tiny hair-like structures (stereocilia) that sit on top of hair cells in the inner ear are damaged by noises that are ... Jan 25, 2022 ... Bending the stereocilia toward the kinocilium depolarizes the cell and results in increased afferent activity. Bending the stereocilia away from ... Nov 3, 2021 ... ... stereocilia. Sound vibrations cause the stereocilia to sway, which leads to the hair cell sending signals to nearby neurons that relay ... PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing. Nature Comm. 10: 3801. 153. György, B., Nist-Lund, C., Pan, B., Asai ...