How can we translate basic science discoveries about stereocilia into meaningful clinical applications?

Jul 8, 2022 ... Inside the inner ear is the cochlea, which is lined with tiny hair cells called stereocilia. The stereocilia's job is to convert sound waves ... Nov 7, 2011 ... The output of the cochlea is controlled by the bending of inner‐hair‐cell (IHC) stereocilia, but the mechanisms that produce this bending ... Jan 25, 2016 ... ... stereocilia. While functionally very different, the protein complexes that organize microvilli and stereocilia have striking parallels. Both ... Aug 11, 2015 ... 2 Answers 2 ... Stereocilia are basically modified microvilli. They are much longer than microvilli, and lack the villin protein. According to ... For the latter option to work without downtime, each stereocilium (or sets of mechanically-connected stereocilia) must be able to execute the recovery by itself ... Oct 19, 2022 ... GPSM2-GNAI(GDP), in turn, imparts asymmetry to the forming stereocilia to enable sensory function in hair cells. INTRODUCTION. Hair cells (HCs) ... Jan 21, 2021 ... Abstract. Inner ear hair cells detect sound-induced displacements and transduce these stimuli into electrical signals in a hair bundle that ... ... stereocilia; GZ, Golgi zone; NF, not found; GalTase, galactosyltransferase; α-SMA, alpha smooth muscle actin; Cx43, connexin-43; BP, basal part; VEGF ... Sep 8, 2022 ... Stereocilia transform audio waves of sound into electrical impulses ... Our cells rely on a healthy supply of blood throughout our body, and this ... They are distinct from cilia and microvilli, but are closely related to microvilli. They form single "finger-like" projections that may be branched, with normal ...