How can the microbiome be manipulated to prevent or treat Pseudomonas aeruginosa infections?

Antibiotics with a novel mode of action will be needed to avoid cross resistance against currently used therapeutic agents. Importantly, antivirulence drugs are ... Oct 12, 2022 ... PAO1 and PA14 are common laboratory reference strains, modeling moderately and hyper-virulent phenotypes, respectively. abstract. The wbp gene cluster, encoding the B-band lipopolysaccharide O antigen of Pseudomonas aeruginosa serotype O5 strain PAO1, was previously shown to ... Lipopolysaccharides from Pseudomonas aeruginosa 10 purified by phenol extraction. All Photos(4) About This Item Multidrug efflux pumps are among the main Pseudomonas aeruginosa antibiotic-resistance determinants. Besides, efflux pumps are also involved in other ... Mar 31, 2015 ... We establish the P. aeruginosa essential genome with statistical precision in laboratory media and CF sputum. Pseudomonas aeruginosa is an important nosocomial pathogen that causes serious nosocomial infections and contributes significantly to morbidity and mortality. Pseudomonas aeruginosa strain Boston 41501 was isolated from blood culture. This whole-genome sequenced bacterial strain has applications in media and ... Pseudomonas aeruginosa infections are the predominant driver of CF lung disease, and airway isolates are frequently resistant to multiple antimicrobials ... Some P. aeruginosa are becoming more resistant to even antibiotics of last resort, and are described as multidrug-resistant.