How can targeting bacterial metabolism be a strategy for developing new antimicrobials?

Jul 5, 2024 ... A series of epidemic clones emerged and expanded between 1850 and 2000, indicating recent selective pressures, possibly driven by industrialization, associated ... Jan 20, 2023 ... Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and virulence, yet this nutrient is sequestered by the ... Pseudomonas aeruginosa is an important nosocomial pathogen that causes serious nosocomial infections and contributes significantly to morbidity and mortality. Pseudomonas aeruginosa are strains of bacteria that are widely found in the environment. Pseudomonas is a major cause of lung infections in people with ... Dec 16, 2024 ... ... infection due to P aeruginosa. Secondary outcomes included all ... Pseudomonas aeruginosa infection. Infect Drug Resist. 2022; 15:655 ... Our results suggest that ExoS facilitates P. aeruginosa penetration through the intestinal epithelial barrier by binding to FXYD3 and thereby impairing the ... Aug 8, 2023 ... Its predilection to cause infections among immunocompromised hosts, extreme versatility, antibiotic resistance, and a wide range of dynamic ... Antibiotics with a novel mode of action will be needed to avoid cross resistance against currently used therapeutic agents. Importantly, antivirulence drugs are ... Jul 5, 2018 ... aeruginosa. For many people, a Pseudomonas infection will only cause mild symptoms. However, if a person is in a hospital or has a weakened ... The bacteria are found widely in the environment, such as in soil, water, and plants. They usually do not cause infections in healthy people. If an infection ...