What are the long-term consequences of severe liver damage from paracetamol overdose?

Jan 5, 2022 ... It is safe to use an ingested dose of > 150 mg/kg as the cut-off value for N-acetylcysteine treatment with risk stratification for hepatotoxicity. ... paracetamol overdose. Serum levels of digoxin-like immunoreactive substances were significantly increased in both viral hepatitis and paracetamol overdose ... Aug 26, 2024 ... Acute poisoning: where a patient self-harms by taking a single large dose of paracetamol, or staggered overdose (several ingestions over greater ... Using data from two prospective cohort studies, we assessed the potential for biomarkers to stratify patients who overdose with paracetamol. Oct 21, 2005 ... The majority ingested more than 10 g of paracetamol. It is thought that paracetamol hepatotoxicity occurs only when >125 mg/kg is absorbed. Feb 23, 2018 ... Children aged under five years who are acutely unwell are particularly vulnerable to paracetamol toxicity, which can lead to liver failure and ... Apr 18, 2018 ... A new in silico paracetamol toxicity identification framework is described to simulate the PK/PD behavior of paracetamol and a panel of corresponding toxicity ... Abstract. A patient is described where oesophageal varices developed and bled 13 days after a paracetamol overdose. The bleeding was unresponsive to medical ... Sep 4, 2021 ... ... paracetamol-induced liver toxicity remains an important clinical problem. The standard clinical treatment framework for paracetamol overdose ... paracetamol overdose.3 Renal effects of paracetamol overdose are less commonly seen than hepatic effects. However, renal impairment may be more common than ...