What are the potential advantages of open-label trials in the development of surgical or device-based interventions?

Dec 1, 2003 ... ... open-label trial. James Cheng-Chung Wei, Tsai Wen Chan, Huey-Shyan Lin, Feng Huang and Chan-Te Chou. The Journal of Rheumatology December ... Oct 3, 2023 ... ENVOL is an open-label, single-arm, two-part study to evaluate the safety and transduction efficiency of systemic gene therapy with commercial ... Carefully designed open-label clinical trials may deliver valuable, high-quality clinical data that can advance the drug development process. Nov 9, 2023 ... Conclusions. These findings suggest that prescribed medical cannabis may have minimal acute impact on cognitive function among patients with ... Mar 4, 2025 ... Inclusion Criteria: ... Unresponsive to ≥2 courses of Bacillus Calmette-Guerin (BCG) therapy within the last 12 months. BCG-unresponsive refers to ... Oct 20, 2023 ... Dermavant presents positive results from Phase 4 open-label trial of VTAMA (tapinarof) cream, 1% for the treatment of intertriginous plaque psoriasis in adults. Jul 9, 2021 ... Phase 1b open-label trial of afatinib plus Xentuzumab (BI 836845) in patients with EGFR mutation-positive NSCLC after progression on EGFR tyrosine kinase ... Open-label trial of Sibeprenlimab for treatment of IgAN. Research type. Research Study. Full title. A Phase 2/3, Multicenter, Open-label Trial to Evaluate the ... For this reason, extreme care needs to be taken regarding how subjects are randomized in open-label trials and randomization methods should be clearly explained ... Open-label studies lack the rigor of blinded studies. Since the lack of blinding can introduce significant bias, reserve the use of open-label studies for ...