What are the challenges in blinding participants and providers in trials evaluating caregiver quality of life?

Addition of primaquine to artemisinin combination treatment did not improve elimination of parasitaemia and prevention of gametocyte carriage. This prospective, open-label clinical trial aimed to evaluate the tolerability and the efficacy of B cell depletion for remission induction in IgG4-RD. May 29, 2024 ... Infusion of mbIL-7-TIL has acceptable safety and potent efficacy in recurrent OC patients who have limited treatment options. The objective of this investigation is to assess the efficacy of coenzyme Q10 as a preventive treatment for migraine headaches. This is a first-in-human, Ph 1/2, open-label, multicenter dose escalation and expansion study in advanced solid tumors. Oct 22, 2024 ... An open trial is a study design where participants and researchers are not blinded to the experiment (Sedgwick, 2014) . All the procedures were ... Triheptanoin dramatically reduced by 90% the number of non-epileptic paroxysmal manifestations over 2 months in GLUT1-DS and improved patient's brain energy ... Donepezil is an effective and safe drug for the long-term symptomatic treatment of mild to moderately severe AD for up to 144 weeks (2.8 years). Jan 1, 2025 ... This open-label study suggests efficacy and safety of psilocybin in severe TRD and supports further study of psychedelics in this population. May 2, 2023 ... A phase II open-label trial of avelumab plus axitinib in previously treated non-small-cell lung cancer or treatment-naïve, cisplatin ...