What are the challenges in attributing changes in mortality to a specific treatment in an open-label trial?

Oct 2, 2010 ... Methods. We undertook an open-label randomised phase 3 trial in men with metastatic castration-resistant prostate cancer who had received ... The objective of this investigation is to assess the efficacy of coenzyme Q10 as a preventive treatment for migraine headaches. Knowledge on rare diseases and orphan drugs · Search for a clinical trial · A Phase 2 Randomized, Open-Label Trial of PA-824-Containing Regimens Versus Standard ... Jan 4, 2024 ... Participants were randomly assigned to treatment with the glucagon-like peptide 1 receptor agonist semaglutide or the sodium–glucose cotransporter 2 inhibitor ... We describe two randomised trials where blinded outcome assessment was not possible, and discuss the strategies used to reduce the possibility of bias. Open-label trial ... An open-label trial, or open trial, is a type of clinical trial in which information is not withheld from trial participants. ... In particular ... MISSION: A Phase 2, Open-Label Trial to Evaluate Safety of Epcoritamab Monotherapy in Subjects with Relapsed or Refractory Diffuse Large B-Cell Lymphoma and ... The purpose of this preliminary study is to examine the active music therapy on cognition and neuropsychiatric symptoms in the elderly with mild and moderate ... Oct 30, 2019 ... The study included children aged between 8 and 17 years, with moderate to severe psoriasis, given tofacitinib 5 mg orally twice daily for at least 36 weeks. An open-label, proof-of-concept phase II clinical trial was conducted in 10 PAP patients. The intervention consisted of two intravenous infusions of rituximab ( ...