What are the challenges in assessing functional status in an open-label trial?

Knowledge on rare diseases and orphan drugs · Search for a clinical trial · A Phase 2 Randomized, Open-Label Trial of PA-824-Containing Regimens Versus Standard ... Mar 4, 2025 ... Inclusion Criteria: ... Unresponsive to ≥2 courses of Bacillus Calmette-Guerin (BCG) therapy within the last 12 months. BCG-unresponsive refers to ... Donepezil is an effective and safe drug for the long-term symptomatic treatment of mild to moderately severe AD for up to 144 weeks (2.8 years). Apr 20, 2023 ... Open-label clinical trials are appropriate when randomization of treatments may be difficult, or if it's important to test long-term effects or safety profiles. Oct 22, 2024 ... An open trial is a study design where participants and researchers are not blinded to the experiment (Sedgwick, 2014) . All the procedures were ... Sep 17, 2024 ... Sarah Howlett discussing the trial design of STAMPEDE2, a phase 3, randomized, open-label trial of niraparib-abiraterone acetate + prednisolone ... Open-label trial of Sibeprenlimab for treatment of IgAN. Research type. Research Study. Full title. A Phase 2/3, Multicenter, Open-label Trial to Evaluate the ... We describe two randomised trials where blinded outcome assessment was not possible, and discuss the strategies used to reduce the possibility of bias. Mar 2, 2018 ... An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas. Jarrod D ... Study design. CONSERVE was a 1:1 randomized, controlled, open-label, international, multicenter trial at 22 hospitals and cardiology practices in North America, ...