What are the benefits of open-label trials for rare diseases or small patient populations?

Mar 2, 2018 ... An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas. Jarrod D ... Mar 8, 2024 ... This randomized open-label trial aimed to replicate this result in a sample of patients with risk factors for stroke (RFS). METHODS. Twenty ... This prospective, open-label clinical trial aimed to evaluate the tolerability and the efficacy of B cell depletion for remission induction in IgG4-RD. May 29, 2024 ... Infusion of mbIL-7-TIL has acceptable safety and potent efficacy in recurrent OC patients who have limited treatment options. Oct 3, 2023 ... ENVOL is an open-label, single-arm, two-part study to evaluate the safety and transduction efficiency of systemic gene therapy with commercial ... Nov 2, 2023 ... Interim Analyses from the Beacon Trial: A Phase 2, Randomized, Open-Label Trial of Bitopertin in Erythropoietic Protoporphyria. Gayle Ross ... An open-label randomised-controlled trial of azathioprine vs. mycophenolate mofetil for the induction of remission in treatment-naive autoimmune hepatitis. Eligibility Requirements. Inclusion Criteria. Subjects must meet all the following criteria for enrollment in the study: - Eastern Cooperative Oncology Group ... Jul 31, 2024 ... The main aim is to test how safe and effective the medicine ILUVIEN® (190μg) is for children and adolescents, who have non-infectious ... Oct 30, 2019 ... The study included children aged between 8 and 17 years, with moderate to severe psoriasis, given tofacitinib 5 mg orally twice daily for at least 36 weeks.