How can instrumental variables be used to address unmeasured confounding in open-label studies?

A MULTICENTER, RANDOMIZED OPEN-LABEL TRIAL COMPARING 1-DAY CESSATION OF DIRECT ORAL ANTICOAGULANTS BEFORE AND AFTER COLORECTAL POLYPECTOMY -MADOWAZU TRIAL-. A randomized, multicenter, open-label trial to determine peritonitis rate, product defect, and technique survival between ANDY-Disc® and UltraBag® in patients ... Jun 3, 2022 ... This open-label pilot study investigated whether practicing yoga in a class results in change in patients with alexisomia and alexithymia. Apr 20, 2023 ... Open-label clinical trials are appropriate when randomization of treatments may be difficult, or if it's important to test long-term effects or safety profiles. Nov 17, 2020 ... We conducted a prospective, randomized, open-label, multicenter trial of favipiravir for the treatment of COVID-19 at 25 hospitals across Japan. We describe two randomised trials where blinded outcome assessment was not possible, and discuss the strategies used to reduce the possibility of bias. Open-label studies lack the rigor of blinded studies. Since the lack of blinding can introduce significant bias, reserve the use of open-label studies for ... Treating Foot Infections in Diabetic Patients: A Randomized, Multicenter, Open-Label Trial of Linezolid versus Ampicillin-Sulbactam/Amoxicillin-Clavulanate. Perlmutter Cancer Center · Clinical Trials & Research Studies · Phase I open-label trial evaluating BI 1810631 as monotherapy in the treatment of patients with ... Dec 1, 2023 ... Neurona Therapeutics Presents New Clinical Data from First Cohort in Ongoing Phase I/II Open-Label Trial of NRTX-1001 Cell Therapy for Drug- ...