How can we foster innovation and accelerate the development of new therapies for neurological and psychiatric disorders?

This article reviews the latest studies concerning the characterization of endothelium-derived hyperpolarizing factors, the mechanisms of factor release and ... Mitochondrial hyperpolarization (MHP), an early event of T-cell activation and death, appears to be mediated through inhibition of F0F1-ATPase or ... Mar 27, 2023 ... Hyperpolarized 13C MRI is an emerging powerful molecular imaging strategy that allows safe, non-radioactive, real time and pathway-specific ... Hyperpolarization—that is, an increase in negative charge on the inside of the neuron—constitutes an inhibitory PSP, because it inhibits the neuron from firing ... Jan 17, 2022 ... We introduce a way to synthesize a fully deuterated, 15 N labelled amino acid derivative and the possibility to polarize the 15 N by means of hydrogenation ... Jun 5, 2013 ... ... hyperpolarization of the spins of carbon-13 nuclei located near synthetic defects in diamond crystals. This spin hyperpolarization, which ... Partisanship is a person's self-identification with a political party. Polarization is the divergence (the gap) between ideological extremes. Jun 7, 2023 ... The purpose of this study is to assess the feasibility of an interleaved acquisition of 31 P MRSI and 23 Na MRI. Hyperpolarized 13 C magnetic resonance spectroscopic (MRS) imaging has emerged as a complementary metabolic imaging approach. The brief dip in the membrane potential below the normal resting voltage is termed hyperpolarization. Action potentials propagate a signal along the length of ...