How can we develop more specific and targeted AMPK modulators?

Mar 1, 2024 ... MK-8722 acts as an effective antiviral against SARS-CoV-2 infection, even when applied post-exposure, paving the way for preclinical tests aimed at inhibiting ... May 20, 2021 ... This study presents a state-of-the-art computational model for investigating the interactions among signaling pathways and environmental stimuli Jul 10, 2019 ... The canonical AMP-dependent mechanism of activation requires the upstream kinase LKB1, which was identified genetically to be a tumour ... Dec 8, 2023 ... As described earlier, AMPK is a potent negative regulator of the inflammatory function of macrophages and promotes the polarisation of ... We show that caloric restriction inhibits progressive loss of heart function, even when started after heart failure is already established. Feb 26, 2020 ... AMPK plays a crucial role in regulating Zika virus replication - a study from our lab published recently in the Journal of Immunology. Aug 2, 2017 ... Nutrient availability influences intestinal epithelial stem cell proliferation and tissue growth. Increases in food result in a greater ... Sep 10, 2020 ... Metformin treatment of primary hepatocytes and intact murine liver requires AMPK regulation of both RAPTOR and TSC2 to fully inhibit mTORC1, and ... Sep 18, 2015 ... The LKB1/AMPK pathway is involved in the process of tumor invasion and migration, which is an important hallmark of carcinoma progression to higher ... AMPK switches on catabolic pathways that generate ATP and switches off ATP ... AMPK activation on HSC has not been established. Aim of this study was ...