What is the role of AMPK in regulating stem cell fate decisions?

Jul 17, 2024 ... Comments46 · Podcast: Erectile Function and Dysfunction · Podcast: The Anti-Aging Pathways of AMPK (Part 2) · Podcast: How to Prevent Cellular ... Jan 15, 2019 ... AMP-activated protein kinase, or AMPK, is known as a master regulator of metabolism. Cells activate AMPK when they are running low on energy, ... Dec 8, 2021 ... The energy sensor AMP kinase (AMPK) and the master scaffolding protein, AXIN, are two major regulators of biological processes in metazoans. Our data indicate that metformin induces ALL cell death by triggering ER and proteotoxic stress and simultaneously down-regulating the physiologic UPR response. Aug 6, 2021 ... AMPK is an integrative metabolic sensor that maintains energy balance at the cellular level and plays an important role in orchestrating intertissue metabolic ... Dec 8, 2023 ... As described earlier, AMPK is a potent negative regulator of the inflammatory function of macrophages and promotes the polarisation of ... Feb 24, 2025 ... ( A ) Representative traces of WT BSM contraction in response to EFS ( n = 4) before (blue) and after (red) exposure to AMPK inhibitor ... LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 ... We recently demonstrated that the LKB1 tumour suppressor kinase, ... Jun 15, 2017 ... In response to energy stress, AMPK restores ATP levels by acutely inhibiting ATP-consuming biosynthetic pathways while simultaneously activating ... AMPK is an important sensor of decreased energy charge in cells and subsequently acts to increase catabolic reactions and decrease anabolic reactions. PGC-1α is ...