What are activity-based probes for acyltransferases and deacylases?

In combination with one of the strong acylating agents, the nucleophilic amines with no NH bonds undergo a fast acylation reaction that gives a cationic acyl ... Auto-S-fatty acylated proteins represent a new class of potential drug targets, which often harbor lipid-binding hydrophobic pockets and reactive cysteine ... Feb 10, 2025 ... Mapping anthocyanin acylation and glycosylation loci. A) GWAS for anthocyanin acylation expressed as % of acylated anthocyanin (over total ... ... acylation. In this work we combine computational methods with experimental ... Acylation of the Endoplasmic Reticulum Chaperone Calnexin. PLoS Comput ... Jul 21, 2022 ... Results · K-Ras(G12S) is an oncogenic driver with GTPase activity · A β-lactone ligand acylates the mutant serine · Optimized β-lactone ligands ... Oct 10, 2021 ... A new study published in Developmental Cell investigates S-acylation of the SARS-CoV-2 S protein. The RayBio® S-Acylation Detection Kit uses a modified 'biotin-switch' (acyl-biotinyl exchange (ABE)) method to allow for the direct visualization of acylated ( ... Apr 30, 2024 ... Acylation is the process of integrating an acyl group (RCO-) into a specific compound. This reaction primarily involves the substitution of a nucleophile. Mar 19, 2023 ... Question: What is the correct order of events in lab session 1 (see slide 4 and notes page)? Boc installation, neutralization, acylation ... ... acylation [11-13]. Indeed, a database of all known S-acylated proteins has ... acylation to become membrane associated. In some cases, this membrane ...