How does the structure of the nucleophile affect reactivity? What are examples of acyl transfer reactions in biochemistry?

A: for transmembrane proteins, S-acylation may allow a cytosolic NH2 or COOH terminus or intracellular (IC) loop of a protein to associate with the membrane ... Chemistry support for Obsidian. Rendering SMILES strings into chemistry structures. - obsidian-chem/README.md at main · Acylation/obsidian-chem. Acylation is another important electrophilic reaction for the substitution of arenes. The electrophilic reagent, an acyl cation, is stabilized by resonance. ... acylation: structural information from theory and experiment. Hui Zhu. Dept. of Chemistry and Biochemistry, University of California, Merced, USA. Search ... Jul 21, 2022 ... Results · K-Ras(G12S) is an oncogenic driver with GTPase activity · A β-lactone ligand acylates the mutant serine · Optimized β-lactone ligands ... Aug 22, 2024 ... What is the right way to create a topology for the protein with an acylated amino acid (serine acylated with palmitic acid)? It seems to be complicated for me. The reaction is named after the French chemists Charles Friedel and James Crafts who discovered it in the late 19th century. The process involves three main ... May 4, 2021 ... We previously reported the development of ultra-long-acting fatty diacid acylated insulin analogs (hereafter ultra-long insulin analogs) for oral use. Apr 30, 2024 ... Acylation is the process of integrating an acyl group (RCO-) into a specific compound. This reaction primarily involves the substitution of a nucleophile. Oct 10, 2021 ... A new study published in Developmental Cell investigates S-acylation of the SARS-CoV-2 S protein.