How can one design a selective acylation reaction?

Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, ... An important caveat for all approaches that involve the incorporation of fatty acids is that more than just lysines can be fatty acylated. Cysteine ... Auto-S-fatty acylated proteins represent a new class of potential drug targets, which often harbor lipid-binding hydrophobic pockets and reactive cysteine ... A: for transmembrane proteins, S-acylation may allow a cytosolic NH2 or COOH terminus or intracellular (IC) loop of a protein to associate with the membrane ... Feb 15, 2023 ... ... acylated, meaning that an acyl group is added to the sugar ... Acylation. Journal of Agricultural and Food Chemistry, 2022; 71 (2): ... by way of acylation with simple achiral acylating agents. Based on the experimental results observed, a transition state (TS) model involving π-interactions ... Apr 25, 2016 ... Acylation is the general term for substitution of acyl group, R-CO- on amino or hydroxyl group of an organic acid whereas acetylation is the ... Thus, while the Friedel-Crafts acylation of benzene requires aluminum chloride as a catalyst, ferrocene can be acylated by acetic anhydride under milder ... Sep 18, 2024 ... Acylation is a chemical reaction in which an acyl group (RCO-) is introduced into a molecule. The acyl group contains a carbonyl group (C=O) ... Log In. acylate. verb. ac·​yl·​ate ˈa-sə-ˌlāt. acylated; acylating. transitive verb. : to introduce an acyl radical into. acylation. ˌa-sə-ˈlā-shən. noun ...