What are mutations in developmental genes? How do mutations affect stem cells?

Researchers identified a gene on the X chromosome that, when flawed (mutated), causes Duchenne, Becker, and an intermediate form of muscular dystrophies. Myeloproliferative neoplasms (MPNs) are blood disorders caused by an excessive production of blood cells in the body. There are a number of gene mutations, ... Mutations may also result from substitution, insertion or deletion of segments of DNA due to mobile genetic elements. Oct 16, 2023 ... Let's explore some of the common causes of mutations, which can include everything from external factors like UV radiation and viruses to internal errors ... Apr 1, 2025 ... Every human has both the BRCA1 and BRCA2 genes. Despite what their names might suggest, BRCA genes do not cause breast cancer. In fact, these ... Sep 12, 2024 ... JAK2 mutations lead to health conditions, including myeloproliferative neoplasms (MPNs), a type of blood cancer. Many people with MPNs have a JAK2 mutation. Smoking tobacco and exposure to UVB radiation through sunbathing, are major factors that can cause mutations. Dec 5, 2017 ... Vaccarino and colleagues theorize that mutations are the result of oxidative stress caused by formation of blood vessels distributing oxygen ... Mar 1, 2023 ... Each of these mutations contributes to the breakdown ... Answer a number of basic questions, such as: What makes the disease process begin? Jan 1, 2008 ... This study identifies two new mutations, confirms SCN4A as a common cause of paramyotonia congenita in the UK, and suggests further allelic ...