What are germline mutations?

Dec 5, 2019 ... Northwestern Medicine scientists have discovered why a specific genetic mutation causes intellectual disability and autism spectrum disorder in children. ... mutations that render the cell with growth and survival advantages. In addition to the loss of function that a mutation in TP53 may cause, many p53 mutants ... Nov 8, 2019 ... Cancer is caused by mutations in our DNA that allow cells to grow uncontrollably – and eventually invade surrounding tissue. Mar 11, 2025 ... PolG disease is caused by inherited mutations in the POLG gene. Currently, over 200 disease-causing POLG mutations are known. POLG ... When a virus replicates, and the end copy has differences (in DNA or RNA), those differences are mutations. ... What Causes Viruses to Mutate? Virus changes are ... Apr 1, 2025 ... Every human has both the BRCA1 and BRCA2 genes. Despite what their names might suggest, BRCA genes do not cause breast cancer. In fact, these ... Causes. Thalassemia is caused by mutations in the DNA of cells that make hemoglobin — the substance in red blood cells that carries oxygen throughout your body. These studies suggest cardiomyopathy is caused by genetic mutations, toxic substances, and molecular abnormalities related to various cellular functions. Apr 23, 2019 ... What are the behavioral and lifestyle factors that cause cancer? A handful of behavioral factors may lead to genetic mutations and cancer ... Jan 18, 2022 ... Most classic Rett syndrome cases are caused by a mutation within the Methylcytosine-binding protein 2 (MECP2) gene.