What is the role of B cells in drug allergies?

When a naïve or memory B cell is activated by an antigen, it proliferates and differentiates into an antibody-secreting effector cell, known as a plasmablast or ... Dec 15, 2020 ... BCDTs such as those targeting CD20, CD19 and BAFF are now used to treat autoimmune diseases, including systemic lupus erythematosus and multiple sclerosis. Feb 7, 2025 ... Researchers explore the role of B cells in non-lymphoid tissues, revealing new insights into infections, cancer, potential therapeutic breakthroughs. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL) in the United States and worldwide, accounting for about 22 percent ... Dec 18, 2020 ... B cells can directly present tumor-associated antigens to T cells or produce antibodies that increase antigen presentation to T cells or kill tumor cells. As a result, VA expanded chronic lymphocytic leukemia to include all chronic B-cell leukemias as related to exposure to Agent Orange or other herbicides during ... Feb 19, 2018 ... Targeting of BTK, which has a central role in several signaling pathways in B cells, particularly the BCR, has shown impressive efficacy as ... Jun 18, 2019 ... T-cell lymphomas. T cells, much like B cells, are vital to our immune system. While B cells produce the antibodies that target diseased cells, T ... CD20 is a B cell-specific membrane protein and represents an attractive target for therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies ... Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology; Director, Center of Molecular and Cellular Oncology; Chief, ...