What are the potential therapeutic targets within the B cell signaling pathways?

A biologic subset of diffuse large B-cell lymphomas with a unique molecular signature or expression profile. In this study, we have shown that EAE disease initiation and progression are differentially influenced by the depletion of B cells from mice with otherwise ... Apr 21, 2015 ... Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL ... Feb 13, 2015 ... The immune system can remember a previously experienced pathogen and can evoke an enhanced response to reinfection that depends on memory lymphocyte ... Feb 1, 2023 ... B Cells. B cells protect you from infection by making proteins called antibodies. B cells are a type of white blood cell called lymphocytes. Oct 11, 2016 ... ... B cells during pathogenic secondary DENV infections is needed. This ... B cells yield plasmablasts and plasma cells (Seifert et al., 2015. The finding gives oncologists a new target for developing immunotherapies: double negative memory B cells, so-called because they are negative for two markers. T cells are responsible for cell-mediated immunity. B cells, which mature in the bone marrow, are responsible for antibody-mediated immunity. This type of activation produces memory and plasma B cells. Naïve B cells bind to soluble or membrane bound antigens and internalize the antigen. The B cell ... Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology; Director, Center of Molecular and Cellular Oncology; Chief, ...