What is the role of B cells in the pathogenesis of chronic diseases?

May 28, 2019 ... Because we used to think that T cells were the major problem, DMTs often target those cells. But now we see that drugs targeting B cells are ... Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology; Director, Center of Molecular and Cellular Oncology; Chief, ... The finding gives oncologists a new target for developing immunotherapies: double negative memory B cells, so-called because they are negative for two markers. Fluorescence in situ hybridization (FISH) is a sensitive method to detect smaller genomic changes associated with various hematological malignancies and solid ... Dec 1, 2018 ... The chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel targets and eliminates CD19-expressing B cells and showed efficacy against B-cell lymphomas. Jun 18, 2019 ... T-cell lymphomas. T cells, much like B cells, are vital to our immune system. While B cells produce the antibodies that target diseased cells, T ... In this study, we have shown that EAE disease initiation and progression are differentially influenced by the depletion of B cells from mice with otherwise ... Jan 4, 2024 ... 10:07 Go to channel Understanding Diffuse Large B-Cell Lymphoma with Bruce Cheson, MD, FACP, FAAAS, FASCO Lymphoma Research Foundation Sep 1, 2008 ... A simple definition of B lymphocytes is a population of cells that express clonally diverse cell surface immunoglobulin (Ig) receptors ... CD20 is a B cell-specific membrane protein and represents an attractive target for therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies ...