What are the ethical considerations in B cell research and therapy?

Oct 5, 2022 ... This article provides an overview of the mechanisms by which the different human antibody subclasses regulate immunity. ... B cells might play a critical role in disease pathogenesis. B cells and their antibodies have undisputed roles in health and disease within the airway ... Dec 1, 2018 ... The chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel targets and eliminates CD19-expressing B cells and showed efficacy against B-cell lymphomas. Sep 1, 2008 ... A simple definition of B lymphocytes is a population of cells that express clonally diverse cell surface immunoglobulin (Ig) receptors ... The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens. Aug 19, 2024 ... This trial represents the largest randomized study of radiotherapy in PMBCL to date. Despite encountering challenges due to unexpectedly good ... Thus, CD40L/CD40 and MHC class II/T cell receptor (TCR) interactions are essential for peripheral B cell tolerance. The decreased numbers of CD4+ regulatory T ( ... This meeting will discuss diverse B cell functions, novel insights into B cell biology, and strategies to exploit B cell function for better health. Feb 13, 2015 ... The immune system can remember a previously experienced pathogen and can evoke an enhanced response to reinfection that depends on memory lymphocyte ... As a result, VA expanded chronic lymphocytic leukemia to include all chronic B-cell leukemias as related to exposure to Agent Orange or other herbicides during ...