How can single-cell RNA sequencing be used to understand B cell heterogeneity?

Jun 18, 2019 ... T-cell lymphomas. T cells, much like B cells, are vital to our immune system. While B cells produce the antibodies that target diseased cells, T ... Feb 13, 2015 ... The immune system can remember a previously experienced pathogen and can evoke an enhanced response to reinfection that depends on memory lymphocyte ... Feb 11, 2025 ... Exhausted B cells may reduce flu vaccine effectiveness. Poor flu vaccine responses in people with immature and exhausted memory B cells may ... Sep 7, 2017 ... The US Food and Drug Administration granted regular approval to tisagenlecleucel (KYMRIAH, Novartis Pharmaceuticals Corp.) for the treatment of patients up to ... Lisocabtagene maraleucel for treating relapsed or refractory large B-cell lymphoma after first-line chemoimmunotherapy when a stem cell transplant is ... Oct 5, 2022 ... This article provides an overview of the mechanisms by which the different human antibody subclasses regulate immunity. Jul 23, 2019 ... ( A ) Histogram and graph displaying TGFβRI expression and MFI of TGFβR1 staining in HEL-specific cells from spleens, pLNs, mLNs, and PPs of ... In the article “α4-integrin deficiency in B cells does not affect disease in a T-cell–mediated EAE disease model" by Hussain et al., first published online ... Nov 29, 2012 ... CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells. CD19 is critically involved in establishing ... Feb 19, 2018 ... Targeting of BTK, which has a central role in several signaling pathways in B cells, particularly the BCR, has shown impressive efficacy as ...