



What factors influence SCFA production in the gut? Can dysfunction of the mast cells in the gut contribute to the start of IBS symptoms?
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what causes ibs to start Informational
- Are there any known triggers for mast cell activation in the gut? Can problems with the breakdown and absorption of fats in the diet contribute to the onset of IBS?
- What types of chemical stimuli are detected by these pathways, and how might altered sensitivity lead to IBS?
- How might its dysregulation be involved in IBS? Can changes in the gut's response to calcitonin gene-related peptide (CGRP) contribute to the onset of IBS symptoms by affecting pain and inflammation?
- What components of processed foods (e.g., additives, preservatives, high fat/sugar content) might negatively impact the gut and potentially lead to IBS?
- Are certain individuals more susceptible to developing IBS after using NSAIDs? Is there a link between a history of eating disorders and the subsequent development of IBS?
- Does small intestinal bacterial overgrowth (SIBO) ever precede or trigger IBS?
- Are there any alternative medications for acid reflux that might have a lower risk of contributing to IBS? Can exposure to pesticides or herbicides through food or the environment contribute to the development of IBS?
- Potential IBS Initiators Can a specific illness trigger the onset of IBS?
- What is the role of the lymphatic system in the gut?
- How might temperature affect gut motility and sensitivity?
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