What is lipotoxicity in the context of steatosis?
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what is steatosis Informational
- What are the research gaps in our understanding of the role of epigenetics in the pathogenesis of metabolic fatty liver disease? How might epigenetic-based therapies be combined with other treatments for NASH?
- How can community-based interventions help in managing steatosis? What is alpha-1 antitrypsin deficiency and its liver involvement, including steatosis?
- What is fibrosis and how is it related to steatosis?
- How do epigenetic changes contribute to the development of steatosis, NASH, and fibrosis? Can environmental factors influence epigenetic modifications in the liver and contribute to fatty liver disease?
- What is the relationship between NASH and hepatocellular carcinoma? How does NASH affect the outcomes of liver transplantation?
- How might the MAFLD classification affect our understanding of the natural history and progression of fatty liver disease? What are the challenges in implementing the MAFLD criteria in routine clinical practice?
- Can steatosis affect the risk of gallstones?
- How do stellate cells contribute to ECM production in response to liver injury? What are the signaling pathways that regulate ECM remodeling in the liver during fibrosis?
- What is the role of inflammation in the systemic effects of steatosis? How does steatosis contribute to systemic insulin resistance?
- What are the risk factors for the progression from steatosis to NASH and fibrosis? How is NASH diagnosed?
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