An epigenetic modification involving the addition of a methyl group to DNA, which can affect gene expression, with genetic variation influencing methylation patterns
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what is genetic heterogeneity Informational
- Identifying reliable biomarkers in the face of heterogeneous disease presentation
- Genetic factors influencing susceptibility to age-related cognitive decline and neurodegenerative disorders
- Genetic risk scores and pathway analysis to understand individual susceptibility
- The binding of a molecule to one site on a protein affecting the activity at another site, with genetic variation potentially altering these interactions
- Identifying genetic factors that predict disease severity, progression, and outcome
- The need to handle large and complex datasets with diverse genetic variants
- Genetic variation affecting different stages of embryonic and fetal development
- Complex genetic interactions contributing to disease susceptibility and heterogeneity in clinical presentation
- DNA sequences that can increase gene expression from a distance, with genetic variation in enhancers or the transcription factors that bind to them affecting gene activity
- Examples of locus heterogeneity What is clinical heterogeneity?
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