what is a template in dna replication
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what is a template in dna replication Informational
- how do post-translational modifications (e.g., phosphorylation, ubiquitination) regulate the activity and interactions of replication proteins at the template
- what are replication stress and how can issues with the template contribute to it
- how do these quality control mechanisms ensure that the genetic information encoded in the dna template is faithfully propagated to daughter cells
- what are the consequences of failures in these quality control mechanisms for genome stability and the potential development of mutations and diseases
- what is the role of the sliding clamp in maintaining contact between the polymerase and the template
- how do chromatin remodeling complexes and histone chaperones facilitate the passage of the replication fork through nucleosomes on the template and the reassembly of chromatin behind it
- how does the packaging of DNA into chromatin affect all stages of dna replication, from initiation to termination, along the template
- what are the key proteins involved in mismatch repair and how do they identify the incorrect base pairing relative to the template
- what are the factors that determine the location and timing of origin firing along the dna template in different cell types and developmental stages
- how does the cell differentiate between the template strand and the newly synthesized strand for mismatch repair
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