



what are the potential consequences of a defective DDR in the context of dna replication and template integrity
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what is a template in dna replication Informational
- how can the study of dna replication in simpler organisms provide insights into the more complex processes in humans, particularly regarding the template
- what are the checkpoints that monitor the integrity of the dna template during replication
- what are the proofreading mechanisms that detect and correct errors in the newly synthesized strand during replication, using the template as the reference
- what are the consequences of low fidelity replication of the template
- how does the three-dimensional organization of the genome in the nucleus affect the coordination of replication of different template regions
- what is the unwinding of the dna template called
- what are histone chaperones and how do they assist in the assembly and disassembly of nucleosomes during dna replication along the template
- how are the ends of linear chromosomes (telomeres) replicated to prevent shortening with each cell division, considering the limitations of template-dependent synthesis
- how is the transition from pre-RC to active replication initiation regulated at the template
- how does the origin of replication relate to the template strands
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