



what are the components of the origin recognition complex (ORC) and how do they bind to the template
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what is a template in dna replication Informational
- how are emerging technologies, such as super-resolution microscopy and single-molecule techniques, contributing to our understanding of dna replication dynamics at the template level
- what are the challenges of replicating the ends of the linear template strands
- how do environmental factors (e.g., UV radiation, chemical mutagens) affect the dna template and consequently replication
- how does the spatial organization of chromosomes within the nucleus influence the efficiency and fidelity of template replication
- how does the replication machinery ensure that the newly synthesized strands are complementary to the template strands
- what are the implications of age-related changes in dna replication fidelity for cellular function and disease susceptibility
- how does mismatch repair further enhance the fidelity of replication based on the template sequence
- what are the consequences of incomplete or inaccurate replication of the dna template
- how does the three-dimensional structure of DNA at replication origins on the template influence the initiation of replication
- how does mitochondrial dna replication differ from nuclear dna replication in terms of the template and machinery
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