



how does the elongation phase of dna replication proceed along the template, with the continuous synthesis of the leading strand and the discontinuous synthesis of the lagging strand
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what is a template in dna replication Informational
- what enzymes are involved in processing Okazaki fragments on the lagging strand template
- what is the role of the nuclear lamina in organizing chromatin and its potential impact on the spatial organization of dna replication
- how is the lagging strand template replicated in short discontinuous fragments
- what are the mechanisms that ensure the coordinated firing of multiple replication origins across the eukaryotic genome on different template regions
- how do prokaryotic and eukaryotic dna replication templates differ
- what is the role of the ubiquitin-proteasome system in regulating the stability and turnover of proteins involved in dna replication and its interaction with the template
- what have comparative genomics and structural biology revealed about the evolution of dna replication mechanisms and their template interactions across different domains of life
- how does the cellular localization of replication proteins change during the cell cycle and how does this relate to the availability of the dna template in different compartments of the nucleus
- what are the different types of DNA lesions that can block or stall replication, and how does the cell respond to these obstacles on the template
- how does the cell ensure that the correct template is used
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