



how do repetitive DNA sequences pose challenges for accurate template replication and genome stability
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what is a template in dna replication Informational
- what are some of the techniques used to study dna replication and the interaction with the template (e.g., pulse-chase labeling, microscopy)
- how many origins of replication are typically found on a eukaryotic dna template
- what is the role of homologous recombination in repairing double-strand breaks that can arise during replication or on the template, using a sister chromatid as a template for accurate repair
- how might understanding the role of the dna template in replication lead to new therapeutic strategies
- what are the downstream effects of activating these checkpoints on cell cycle progression and the repair of template issues
- how does mismatch repair further enhance the accuracy of replication by identifying and correcting base-pairing errors that escape the polymerase proofreading, based on the template strand identity
- can exposure to certain chemicals or radiation lead to persistent damage on the template that affects replication in the long term
- how has the study of bacterial dna replication contributed to our understanding of template-based synthesis
- how can we leverage our knowledge of dna replication and template vulnerabilities to develop more effective diagnostic or therapeutic strategies for these diseases
- what is the role of the ubiquitin-proteasome system in regulating the stability and turnover of proteins involved in dna replication and its interaction with the template
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